How to Use Statins?

Treatment with statins (HMG co-A reductase inhibitors) lowers serum cholesterol substantially and has been shown to reduce myocardial infarction, coronary deaths and overall mortality in recent controlled trials. The purpose of this statement is to help doctors to set priorities for treatment with statins. It is based upon the best evidence available at the moment on clinical effectiveness, cost-effectiveness and long-term safety. It is not intended to replace or override clinical judgement in individual cases. It is also important to take note of local policies where they exist. The aim is to give general advice on those individuals who will benefit from statin treatment, and which groups of patients will benefit most and should...more

Sat, Jul 10,2010

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Statin Treatment in Diabetes Mellitus

As we mark the tenth anniversary of the publication of the Diabetes Control and Complications Trial and the fifth anniversary of the United Kingdom Prospective Diabetes Study, studies which so clearly demonstrate the role of glycemic control in the prevention and delay of microvascular complications, it is interesting to consider what fundamental new concepts in diabetes care have developed. Since the 1970s, there have been substantial epidemiological data demonstrating that cardiovascular diseases (here defined as ischemic heart disease, stroke, and peripheral vascular disease) consitute the primary cause of morbidity and mortality...more

Sat, Jul 10,2010

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Treatment With Statins After Induction of Focal Ischemia in Rats Reduces the Extent of Brain Damage

Luigi Sironi^*; Mauro Cimino^*; Uliano Guerrini; Anna Maria Calvio; Barbara Lodetti; Maria Asdente; Walter Balduini; Rodolfo Paoletti; Elena Tremoli

From the Department of Pharmacological Sciences (L.S., U.G., A.M.C., B.L., M.A., R.P., E.T.), Milan and Institute of Pharmacology and Pharmacognosy (M.C., W.B.), Urbino, Italy.
Correspondence to Elena Tremoli, Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, Via Balzaretti 9, I-20133 Milano, Italy. E-mail elena.tremoli@unimi.it more

Sat, Jul 10,2010

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Cholestrol Treatment with Statins and other drugs

Lifestyle changes such as exercising and eating a healthy diet are the first line of defense against high cholesterol. But, if you've made these important lifestyle changes and your total cholesterol — and particularly your LDL cholesterol — remains high, your doctor may recommend medication.
The specific choice of medication or combination of medications depends on various factors, including your individual risk factors, your age, your current health and possible side effects. Common choices include:

Statins. Statins — among the most commonly prescribed medications for lowering cholesterol — block a substance your liver needs to make cholesterol. This causes your liver to remove...more

Sat, Jul 10,2010

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